Question... what do you find to be the largest difference in handling PixelHobby vs. ironing beads like Perler or Hama? I'm not familiar enough with them, but it looks like you get a tremendous amount more of color options with these.
PixelHobby beads are smaller so I need to use a tweezer to place them in the right spot. So you trade out the speed of Perler beads for the greater detail you get with PixelHobby. As you stated you also don't need to iron which is a not really that big of a deal, after doing enough Perler projects you get fairly good at ironing so really not much to fear in the ironing.
My main reason for using PixelHobby beads is I was running out of room to put my Perler/Hama pieces. They were quickly getting larger and larger and filled up my walls. Using PixelHobby allows me to take more time and they take up less space, so it worked for me.